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KMID : 0043320060290110957
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Archives of Pharmacal Research
2006 Volume.29 No. 11 p.957 ~ p.962
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Synthesis and Anti-HIV Evaluation of the Novel 2-(m-Chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines
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Yan Ren-Zhang
Liu Xin-Yong
Xu Wen-Fang
Pannecouque Christophe
Witvrouw Myriam
Clercq Erik De
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Abstract
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A novel series of 2-(m-Chlorobenzyl)-4-substituted-1, 1, 3-trioxo-2H, 4H-pyrazolo[4, 5-e][1, 2, 4] thiadiazines (7a-k) were synthesized, and evaluated for their anti-HIV replication in MT-4 cell cultures. Compound (7a) showed activity against HIV-1-induced cytopathicity, with an value of , but none of the compounds exhibited inhibitory activity against HIV-2.
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KEYWORD
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Synthesis, Pyrazolothiadiazines, HIV-1, NNRTIs, MT-4 cells
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